Not Found

HTTP Error 404. The requested resource is not found.

_-www.bppa.org-_365体育比分 ?????????协??_365体育比分

?????????|???????????|??协??????|?????????

????????2024/4/20 10:18:56

???位??????>>???????>>???????

11?掳???????泄??????????8???????FDA???

????????12??6?????????????FDA?????????????11?路?FDA????????8???????????6???路?????澹∟ME????2?????????????2019??????FDA???????????????41????2018??????????2019?????????????FDA?????????????????????????

?1??1995??????FDA????????????

????8??????????????“???”????

??1??FDA??????????????

????????????????????11??FDA?????8??????婕�????????????????????????????37.5%???????3??????????11?路??????????????“???”?????????Oxbryta??voxelotor??——???FDA???????????????????????????Adakveo??crizanlizumab-tmca??——?????????P???????????????????Reblozyl??luspatercept–aamt??——???FDA?????????????????????????貌???????Brukinsa??Zanubrutinib??????????????蟹????泄??????????FDA???????????

????????????????????Brukinsa??

??????????Zanubrutinib??????????????????BTK???????????????????????????????????????????????????MCL???????BTK????????????????????????T????胁?????????B???????????????????????????????????????????B????泄??????????械?

???????????????????????????BTK??????????校???????????????????蟹???????????ibrutinib????????????????????acalabrutinib????????????2013????????BTK????????????校????????????????150?????????????????2017????FDA?????2018???????????0.62???????

?????????????????????蟹?????????????????34??械??BTK??????????????????????巍????校??????械?3?????????2?????????????2????????????15???????12????

?2??BTK?????????蟹????

???????????????BTK?械??????18?????校????????围???械??????????????????????????????????????????ICP-022?????????CT-1530??

??2??????????BTK????????????

??????????Oxbryta??Reblozyl

????1??Oxbryta

????2019??11??25???GLOBAL BLOOD THERAPEUTICS????蟹??????Oxbryta??voxelotor???????????????校?????????12???????????????????????????FDA???????????????????????????Oxbryta??眉???????????????????????????????????????????????????FDA????????????????????????????????????????????????

?3??voxelotor??????

????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????voxelotor??????????????????????????????????????????????????????????效?????????????????????????????Voxelotor?????械???????????????Evaluate Pharma?????6???????????Oxbryta??????????????19.8???????

????2??Reblozyl

????2019??11??8???????FDA?????????Reblozyl??luspatercept?????????校??????????????????????????β???泻???????????Reblozyl??FDA????????????????????????β???泻???????????????????????????械??????????????TGF??-β?????????????澹�?????????Smad2/3????路?????????????????????????????????????????

?4??Reblozyl????

????????336??????????????????校?Reblozyl???????????慰????????????????????21%????????????????????33%??????慰?????4.5%??????????????????Reblozyl????????????????????????????????围?????8000??9000?????携??β???泻???????β???泻???????????谐????Reblozyl????????????????Reblozyl????????????????????????????????????MDS??????????????FDA??EMA????????????????????MDS??????????Reblozyl????????????????20???????

????????

???????????????????????????蟹??????????????????????????????????????校?????蟹?????路?????????????????????????械????????????????????效????????????????矛??????????蟹?????????????????????2019???FDA???????????????????????????

(2020/1/6 14:18:01 ?????? ???24928??)

?????????协?? ?????